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Understanding the interactions between treatment-induced autoimmunity and antitumor immunity is key to developing treatments for irAEs
Its targeted mechanism makes it relevant in studies focused on weight management and metabolic health
Even though several studies show an association between the levels of lipid oxidation products and disease progression, experimental evidence suggests that compounds such as reactive aldehydes and cholesterol oxidation products are characteristic features of hepatic oxidative damage [11]
doi: 10.1073/pnas.2308511120 68 SierroFEvrardMRizzettoSMelinoMMitchellAJFloridoMet al
The two compounds act on different and non-competing biological pathways, so there is no pharmacological reason to separate them
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