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This pathway is particularly relevant given that single-cell transcriptome analyses of chronic AD patients have revealed characteristic abnormalities in keratinocyte differentiation and oxidative stress damage [2]

PMID: 325 RanaMSRahmanMMBakerJHoussamiNYuXQMarinovichML

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This elasticity improvement likely reflects both new elastin synthesis and better preservation of existing elastin through reduced oxidative damage and elastase inhibition

A separate narrative review titled "Regeneration or Risk?" acknowledged the promising preclinical evidence but stressed the critical need for larger human trials