Proc Natl Acad Sci USA (2003) 100:15805
This leads to the transcription of genes involved in detoxification, antioxidation, and anti-inflammatory responses ( Figure 2 ) (90)
This decline correlates with disruption of circadian gene expression (CLOCK, BMAL1, PER1/2, CRY1/2) across peripheral tissues, impaired immune surveillance, increased oxidative stress, and accelerated telomere attrition a convergence suggesting that the pineal gland may function as a master regulator of biological aging rate, with telomere dynamics as one downstream output
Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease
Other chemicals, such as ethanol, perchlorate, atrazine, etc., altered or reduced craniofacial cartilage, but the severe defects in this case are similar to those of endocrine disruptors, such as di-butyl phthalate and estradiol