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The mechanisms underlying these potential synergistic effects remain under active investigation and may involve growth factor signaling, extracellular matrix synthesis, or anti-catabolic pathways in joint tissues

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Basic Clin Pharmacol Toxicol 114(3):271280 Zhang X, Liang D, Guo B, Yang L, Wang L, Ma J (2012) Zinc inhibits high glucose-induced apoptosis in peritoneal mesothelial cells