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Ephelides typically appear during childhood (especially between 2 and 4 years of age), and tend to fade by adulthood

Additionally, secretin stimulates brown adipose tissue thermogenesis in rodents and humans [39], and a recent RCT showed that supraphysiological secretin infusion reduced food intake in healthy men [42]

Still, the connection has generated growing interest among researchers and clinicians, particularly as more people taking GLP-1 medications report changes in cravings and reward-related behaviors

This depends on your wellness goals

Patients with certain genetic variants show stronger appetite rebound and benefit from continuous low-dose therapy, while others may succeed with structured breaks or lower maintenance doses