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At the same time, the activity of antioxidant enzymes (SOD, GPX, GR) in cardiomyocytes is weaker than that in other organs [17], further aggravating the susceptibility to this injury

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An open-label study in adult and paediatric patients with Prader-Willi syndrome (a rare genetic disorder that causes a range of physical symptoms, learning difficulties and behavioural problems, including obsessive compulsive symptoms) and SPD also found significant benefits of NAC, 4501200 mg per day for 12 weeks, with 25 out of 35 patients having a complete resolution of skin lesions, and the remaining 10 participants had significant improvements

However, this muscle loss appears to result from the caloric deficit rather than direct muscle breakdown by the medication itself