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However, the possibility that intestinal-produced GLP-1 is secreted into the circulation at concentrations sufficient to activate its receptors on distant target tissues remains a matter of debate as intestinally secreted GLP-1 is rapidly degraded by dipeptidyl peptidase-4 (DPP-4)

Obesity models confirmed the weight-loss efficacy of D13, D41, and D44, with D13 achieving a 19.25% reduction in body weight, similar to Semaglutides 21.54% reduction, while also demonstrating improved glucose tolerance

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Polyphenols also promote the browning of white adipose tissue and enhance thermogenesis, which increases energy expenditure and fat burning (497)

One of the reasons semaglutide is considered safe is the gradual increase in dosage, which helps minimize side effects and allows patients to adapt more comfortably