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[11] found that plasma 5-HT concentration was inversely correlated with stool frequency and directly correlated with pain threshold in IBS-C patients, suggesting that serotonin dysregulation contributes to visceral hypersensitivity and pain perception in IBS-C

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miR-122 has been well-known to play a role in liver physiology and to be suppressed in primary hepatocellular carcinoma (HCC) suggesting that miR-122 has a tumor suppressor role (Wang et al., 2012)