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The highest incidence and the high-grade irAEs are usually associated with combination therapy of ipilimumab plus anti-PD-1/PD-L1 (36)

Acknowledgments This work was supported in part by grants PUJ IDs 4509 and 4327 to GEB

Betaine has been shown to suppress the expression of proinflammatory cytokines such as TNF- and IL-6 via inhibition of the NLRP3 inflammasome pathway, thereby attenuating hepatic inflammation

According to one study, the most common side effects are gastrointestinal issues, including: Nausea Vomiting Diarrhea Abdominal pain Rare, but more serious side effects can include allergic reactions, thyroid tumors, and pancreatitis (inflammation of the pancreas)

Semaglutide is an injectable medication for weight loss