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However, GLP- 1-mediated improvements in blood flow were considerably attenuated after a 2-month period of better glycemic control [62]

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Previous studies have identified synoviolin (SYVN1) and STIP1 homology and U-box-containing protein 1 (STUB1) as key E3 ubiquitin ligases responsible for the ubiquitin-mediated proteasomal degradation of GLUD1 [10, 16]

Our findings also demonstrate distinct patterns in incretin hormone responses, with early postoperative increases in GLP-1 and GIP that gradually declining over time (changes that may be associated to WR in a subset of patients)