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25.57 Dermal nevus: the formation of pseudovascular spaces as shown in this example is a common artifact

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Hypertrophic adipocytes can promote the infiltration of macrophages into adipose tissue, thereby creating a local microenvironment characterized by a pro-inflammatory state, manifested by increased production of various cytokines, including tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and chemokines

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La primera es endgena , es decir, el cuerpo es capaz de producirla