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Por otro lado, aunque una limitante fue el no contar con un tamao de muestra adecuado, vale la pena mencionar que sta en nuestro estudio sigue siendo mayor a la observada en la mayora de los estudios (menor a 15 participantes) y donde tampoco hacen mencin a un clculo de tamao de la muestra

This work was supported by the Science and Technology Planning Project of Guangzhou (No

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Defects in both UPR signaling and ERAD have been strongly implicated in neurodegenerative diseases, including Alzheimers disease and amyotrophic lateral sclerosis (ALS), highlighting the clinical relevance of maintaining proper ER zinc homeostasis 126,127,128