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Then, L-theanine alone or in combination with theobromine could effectively inhibit tumor production in male Wistar rats with colon cancer induced by dimethylhydrazine, and the mechanism of action was related to downregulating the Akt/mTOR (mammalian target of rapamycin) and JAK2/STAT3 pathways and increasing the mRNA and protein expression of tumor suppressor Smad2 (73)

The peptide can be used alongside metabolic support compounds like MOTS-c for mitochondrial enhancement without concerns about compounding effects on glucose or IGF-1

Elevated blood levels of MMA (greater than 0.37 umol/L) may indicate vitamin B12 deficiency

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The neuroprotective effects appear partially mediated through IGF-1 elevation secondary to GH release, as IGF-1 is a well-established neuroprotective factor with effects on neuronal survival and synaptic plasticity