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Notably, retatrutide trials showed an overwhelming clearance of liver fat, with some cohorts experiencing up to an 80% reduction in hepatic lipid content, presenting a massive benefit for individuals dealing with metabolic dysfunction-associated steatotic liver disease (MASLD)

Over-the-Counter Remedies That Work Safely With Semaglutide Osmotic laxatives like polyethylene glycol (MiraLAX) and magnesium citrate draw water into the intestinal lumen, softening stool without triggering cramping or urgency

Severe Gastrointestinal Disease: Since semaglutide can exacerbate gastrointestinal symptoms, patients with severe gastrointestinal diseases, such as gastroparesis, should avoid it

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Br J Dermatol 145: 453-462