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While an 11.2 percent average weight loss is clinically significant, it trails behind the 13.7 percent average reduction seen with semaglutide and 20.2 percent with tirzepatide
It remains to be seen whether T1D-MVPs are potential etiologic factors for causing disease or rather are biomarkers
Lee SH (2015) Intestinal permeability regulation by tight junction: Implication on inflammatory bowel diseases
Renal impairment GLP-1 RAs are generally safe in patients with CKD and have demonstrated nephroprotective effects in the FLOW trial, where semaglutide significantly reduced the composite renal endpoint (hospitalization for acute kidney injury, sustained 50% decline in estimated glomerular filtration rate (eGFR), end-stage kidney disease, or renal death) in patients with type 2 diabetes and CKD [15]
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