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doi: 10.1177/1933719111424454 109 Flores-EspinosaPOlmos-OrtzAGranados-CepedaMQuesada-ReynaBVega-SnchezRVelzquezPet al

Patients should contact their GP promptly or call NHS 111 if experiencing persistent vomiting (unable to keep fluids down for 24 hours), signs of dehydration, severe abdominal pain, or any symptoms causing significant concern

Researchers also reported that the significance of semaglutides positive effects on several drinking outcomes was relatively greater than what is normally seen with existing AUD medications

The combination does not require dose adjustments to either medication in most cases, though your doctor may monitor kidney function and adjust metformin dosing if needed based on individual health status