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4.4 Evidence evaluation and limitations The available evidence has important limitations

By altering the AMPK/NLRP3/TGF- signaling, luteolin treatment in diabetic nephropathy led to the mitigation of renal fibrosis by upregulation of phosphorylated AMPK (p-AMPK) and the downregulation of pro-inflammatory and fibrotic markers like p-NF-B, NLRP3, Collagen I, TGF-1, and -SMA [122]

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