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GLP-1 receptor agonist use was associated with a 74% reduction in the odds of alcohol use disorder, a 69% reduction in the odds of opioid use disorder, a 68% reduction in the odds of nicotine use disorder, and a 75% reduction in the odds of cocaine use disorder

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Clinical trials have shown Tirzepatide to be more effective than leading GLP-1 agonists like semaglutide in reducing HbA1c and body weight