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Specifically, when all other exposure variables were fixed at the 75th percentile, if the estimated single-exposure effect of a particular exposure variable increased or decreased compared to when it was fixed at the 25th percentile, then this was considered to indicate significant interactions between that variable and one or more other exposure variables, as described previously [45]

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However, certain situations warrant immediate medical evaluation

However, whether these factors are causally related to CAD has been questioned in MR studies [45, 46], and we found no difference by sex in the risk factors