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The peptide may potentially trigger GHRH receptors GRF (1-29)

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The expression of PGC-1 was reported to be decreased in substantia nigra of PD patients, which could be partially attributed to increased cytosine methylation at the promoter region of the PGC-1 gene (Eschbach et al., 2015

Given this, it is unsurprising that co-administration of NOS inhibitors and SSRIs have synergistic benefits in preclinical models of anxiety and mood (Harkin et al., 2003, 2004