If you typically inject on Saturday morning at 9 AM and you experience semaglutide fatigue on Monday afternoon, that is 54 hours post-injection, a window where plasma levels are still near peak
You might notice the worst symptoms when attempting to grip heavy objects, when carrying items, using the hands at work for many hours (such as when writing, holding up a phone or typing), driving, or doing any hobbies that involve use of the hands
Week one typically shows appetite changes rather than scale movement, with measurable loss becoming visible around day 10-14
Request a DEXA scan at baseline and 12 weeks to track lean mass changes, or use bioelectrical impedance analysis (BIA) if DEXA isn't accessible
The exact reason remains unknown yet it may result from two interacting elements