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Complexation of Al(III) with reduced glutathione in acidic aqueous solutions

Die Mnner nahmen vier Wochen lang zweimal tglich jeweils 100 mg sublinguales Glutathion (OXITION) oder ein Placebo ein

Dissociation constants of polybasic acids and their application to the calculation of molecular dimensions

R Clinical associations of TT homozygosity: Elevated risk of benzene-related leukemia (particularly acute myeloid leukemia) R Increased bladder cancer risk (especially in smokers) R Increased colorectal cancer risk R Poor response to quinone-based chemotherapy drugs (mitomycin C, RH1) because NQO1 activates these prodrugs R Reduced CoQ10 (ubiquinol) recycling capacity R Reduced p53 stabilization R Clinical takeaway: TT carriers should supplement with ubiquinol (not ubiquinone), aggressively support NRF2 through other pathways, avoid quinone-generating exposures (benzene, PAHs), and ensure riboflavin status is optimal to support whatever residual NQO1 activity exists

thus, expert opinion suggests some level of safety in human subjects may be assumed