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Lal RA, Hoffman AR (2019) Pituitary response to traumatic brain injury

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Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem

This suggests the enzyme plays an active role in maintaining obesity, not just responding to it

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