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ROS are directly or indirectly associated with cytokine storm induction in SARS-CoV-2 infection, and ROS can activate NF-B and NLRP3 inflammasomes, thereby leading to the production of inflammatory cytokines and the development of acute respiratory distress syndrome and multiple organ dysfunction 62,63,64

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In another child who accidentally ingested 400 mg/kg VPA, decreased -oxidation and markedly increased -oxidation were also observed, and the concentration of 4-en-VPA was markedly increased, although there was neither hyperammonaemia nor signs of liver dysfunction [70]