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Once-weekly exenatide: an extended-duration glucagon-like peptide agonist for the treatment of type 2 diabetes mellitus

revealed that the use of a novel REDOX selective APE1 inhibitor in vitro and in vivo could effectively reduce the progression of bladder cancer, and the combination of this inhibitor with cisplatin, a commonly used chemotherapy drug, was more effective than cisplatin alone [26]

*Measured as IC 50 (concentration of inhibitor to produce 50% of inhibition)

doi: 10.1016/s0076-6879(02)48630-2

Based on 77,690 independent reflections of better than 10 A resolution, a final R-factor of 18.6% was obtained with a model obeying standard geometry within 0.025 A in bond lengths and 2.4 degrees in bond angles