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While it is difficult to identify one single mechanism responsible for temperature-enhanced limb lengthening, it is likely the effect is driven by multiple direct and indirect mechanisms such as altered cell kinetics, gene expression, vascularization, transport of nutrients and growth factors [122], and systemic hormone concentrations [4]

[PubMed: 11231320] 54

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doi: 10.1038/s41426-018-0063-8 88 JossetL.MenacheryV