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Yes, GLP-1 medications commonly cause changes in bowel movements, though the nature and severity of these changes vary significantly among patients

In comparison, no case of pancreatitis was reported in the placebo group

335,336 The expression of iNOS is primarily activated by the NF-B pathway, which is activated and translocated to the nucleus upon inflammatory stimulation (such as bacterial endotoxins or pro-inflammatory cytokines), thus increasing the transcription and expression of iNOS

In preclinical models of polymicrobial sepsis, such as the cecal slurry and cecal ligation puncture (CLP) models, long-acting GLP-1 receptor agonists (GLP-1RAs) like semaglutide have demonstrated protective effects

Rondas, D., DHertog, W., Overbergh, L