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2.10 Analytical ultracentrifugation (AUC) Analytical ultracentrifugation (AUC) was invented in the 1920s by Theodor Svedberg (18841971), who developed the first analytical ultracentrifuge to determine the molecular weight and analyze the sedimentation behavior of disperse systems and macromolecules, such as proteins and colloids (Svedberg and Nichols, 1923

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