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Importantly, estrogen has also been shown to enhance memory function, specifically in hippocampal mechanisms [51]

Development was discontinued after the compound repeatedly failed to convert its consistent GH/IGF-1 effect into approved clinical benefit most visibly a completely negative 563-patient Alzheimers trial and after a hip-fracture Phase IIb study was terminated early for a congestive-heart-failure safety signal

DNA analysis of COL3A1 including MLPA and COL1A1 was normal in two patients (P6, P8) with esophageal rupture and/or bowel rupture

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