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2. Use in AM/PM

GLP-1 By activating an incretin signaling pathway, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) modulate blood glucose levels [10]

Slower titration to avoid abrupt glycemic swings or lower maintenance doses in individuals at highest risk merit formal evaluation. Ong and Pasquel also underlined the need for strong synergy between diabetes care providers and ophthalmologists, as such collaborations may allow timely IRA dose adjustments rather than abrupt initiation or discontinuation, which itself may worsen cardiometabolic risk. The path forward is one of balance: preserve the broad advantages of IRAs and their successors while prospectively elucidating, stratifying and mitigating ocular risk, they concluded

PLOS ONE 10(8):e0136816 Yang J, Wang K, An Y, Wu R, Li J, Wang H, Dong Y (2022) Mst1/2 is necessary for satellite cell differentiation to promote muscle regeneration

Semaglutide works by mimicking the action of a hormone called GLP-1 (glucagon-like peptide-1)