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Among them, two peroxisome proliferatoractivated receptor agonists (PPARs), namely Seladelpar and Elafibranor, have gained approval for use, showing biochemical response, namely alkaline phosphatase (ALP) normalization, in non-responders and improvement of pruritus

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Post-trial follow-up data from EMPA-KIDNEY suggest that cardiorenal benefits may persisted for up to 1 year after treatment cessation, highlighting the importance of continued therapy for long-term effectiveness [117]

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