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Extraction was performed by rotation of tubes at room temperature by 24 h, at 30 rpm in Multi RS-60 Rotator (Biosan, Riga, Latvia) and next centrifugation at relative centrifugal force 12,333g by 10 min using an Eppendorf 5810R centrifuge (Eppendorf, Hamburg, Germany)

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Pooled analysis of SCALE found that older adults had greater gastrointestinal disturbance than younger adults [84]

While these adverse events are significant, FAERS data alone doesnt establish a direct causal link between the medications and the reported fatalities