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5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD

B12 is essential to nerve health, so it makes sense that a deficiency would impact optic nerve health as well

Side Effects: Irregular bowel movements Feeling of vomit Swelling on the body Headache Serious Side Effects: Increase in the rate of heartbeat Pain in the chest Increase in weight Weakness in muscles Pain in the muscles and joints Excessive thirst Urinating frequently Breathlessness Feeling extremely tired Swollen arms, legs, and hands Vitamin B12 Injection Drug Interactions: folic acid cimetidine potassium supplements neomycin colchicine People who have AIDS are more prone to having Vitamin B12 deficiency.Vitamin B12 injections are not toxic

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Titrating with B12/MIC Patients typically start at a 1ml dose for 4 weeks