This is one of the most common questions I hear as a Registered Dietitian
Bilgin E, Venerito V, Bogdanos DP
On the other hand, GLP-2 analogs due to their effects on crypt cell proliferation, improving intestinal expansion and nutrient absorption, are used for intestinal injury and short bowel syndrome (Litvak et al
In microglia, GLP-1R activation via PI3K/Akt signaling also reduces neuroinflammation by modulating NF-B activity, decreases the production of pro-inflammatory cytokines, increases anti-inflammatory markers such as IL-10, IL-4, Arginase, and CD206, and the transformation of microglia into an anti-inflammatory state
The combination of reduced food intake (and therefore reduced water from food) plus potential gastrointestinal effects means dehydration is a real risk