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Moreover, the overexpression of the mitophagy proteins PINK1 and parkin in microglia was demonstrated to significantly inhibit STING-induced inflammation, reduce the levels of insoluble A 142 and A 140 content, and ameliorate the cognitive deficits in the AD mouse model (Fang et al., 2019)

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Here, the method was applied in a systematic fashion to the 31 amino acid peptide GLP-1 to generate a series of GLP-1-oligourea hybrids among which potent agonists of GLP-1R were identified