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B12 has been suggested to improve metabolic functions

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Although melanin pigment (mostly eumelanin) can scavenge free radicals, this is insufficient to counteract all the cutaneous consequences of ROS, as illustrated by an enhanced oxidative stress in melasma [57, 58]

PLoS One 11(4), e0152429, 10.1371/journal.pone.0152429 (2016)

Bioavailability: The Lens for Every Decision At the end of the day, the debate over which supplement is "better" is secondary to the question: "Is your body actually absorbing this?" A high dose of a poorly absorbed supplement is less effective than a precise dose of a highly bioavailable one