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A minimum of 8 weeks appears necessary to observe meaningful changes in chronic conditions, with 10 to 12 week cycles common

Rotate injection sites to prevent lipodystrophy 9 Store reconstituted solution refrigerated (28C) and use within 28 days Week 12 Initial appetite suppression may begin

Chronic liver disease or acute liver failure can lower factor production, impair vitamin K processing, and produce coagulopathy, leading to easy bruising and bleeding