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121 In fact, studies that have specifically evaluated the impact of exposure to folic acid before and during pregnancy found that the risk of ASD decreased in infants with maternal folic acid supplementation compared to infants without maternal nutritional supplementation

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Translationally, redox proteomics (cysteine-switches in insulin signalling), Prx redox state, F 2 -isoprostanes/HNE adducts and LIP assays (with chelator validation) help stratify patients and monitor interventions such as mitochondrial quality control, NOX isoform targeting and dietary/exercise prescriptions that reset redox tone without erasing adaptive signalling (Holendov et al