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Metabolomics data are provided in the Supplementary Tables 3, 4

Similar content being viewed by others Introduction The intervertebral disc (IVD) arises from the embryonic notochord and mesenchyme and develops into a complex tissue that permits movement between vertebrae and provides flexibility and integrity to the spine [1]

Timeline by Potential Benefit All timelines above are speculative

Corresponding to the sequence Ala-Glu-Asp-Gly and derived from the active fragment of a pineal polypeptide complex, this compound is examined in preclinical models addressing telomere biology, gene expression, and neuroendocrine regulation

Single agent growth-inhibitory effects have been reported in breast, colon, and meningioma tumor xenografts, which suggests that GHR antagonism as a monotherapy may have efficacy in some tumor types