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2 Materials and methods 2.1 Model overview The United Kingdom Prospective Diabetes Study Outcome Model version 2.1 (UKPDS OM2) is a validated computerized simulation tool for evaluating the long-term effects of interventions and complications in patients with T2DM, as well as economic outcomes ( 2.2 Simulation population and treatment inputs We utilized patient characteristics and treatments from a network meta-analysis comparing once-daily oral semaglutide 14 mg to injectable GLP-1 RAs in individuals with poorly controlled T2DM on basal insulin

Walking is central to many GLP-1 treatment plans, so the goal is to make outdoor activity safer, not to avoid it

While there has been extensive research on dietary patterns and weight loss, the most effective intervention is reduction in caloric intake [19]

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