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In patients with the fibrotic disease systemic sclerosis, again TGF--dependent upregulation of COL1A1 and CTGF is conveyed via ALK1/Smad1/5- and also ERK1/2-signal pathways rather than ALK5/Smad2/3-activation (113)

Glutathione is your body's master antioxidant, the compound your cells use to neutralize the damaging byproducts of intense exercise and everyday stress

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Caloric restriction (CR), a reduction in caloric intake without malnutrition or starvation, is the most robust, non-pharmacological and reproducible intervention for extending lifespan in model organisms 3