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When used in topical formulations, the most commonly reported issues are localised and mild, and may include: Skin irritation or redness at the site of application Contact dermatitis in individuals with sensitive skin or known peptide sensitivities Scalp itching or tingling , which may be transient The following precautions are advised: Avoid application to broken, inflamed, or irritated skin , and keep the product away from the eyes and mucous membranes

References & Studies LRetinol (USA, 12 weeks): Reductions in fine lines & pigmentation

Distribution of HSP70, protein kinase C, and spectrin is altered in lymphocytes during a fever-like hyperthermia exposure

These consecutive visits were conducted no later than 15 days after visit 2

Then the samples were processed according to the procedure described in Section Biological samples preparation