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2022 Jan 26;10(3):740-750 Tan H, Chen W, et al

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Without automatic substitution authority, the biosimilar company must deploy a commercial team equivalent in scale to a branded drug launch to specifically drive prescribers toward its product a cost structure that fundamentally undermines the low-price, high-volume generic business model

While injection timing has not been formally studied in relation to sleep, morning dosing aligns peak medication effects with daytime hours when active digestion is less disruptive to sleep