Many commentators assumed that the "Commercial Blockbuster" era was over

Common Side Effects of Semaglutide Use These are the most frequently reported side effects and usually decrease as your body gets used to the medication: Gastrointestinal Issues: Nausea Vomiting Diarrhea Constipation Abdominal pain Appetite Changes: Reduced appetite Changes in taste Fatigue: Feeling tired or fatigued Headache: Mild to moderate headaches Less Common Side Effects These side effects are less common but may still occur: Dizziness: Feeling lightheaded or dizzy Hypoglycemia (Low Blood Sugar): Especially when used with other diabetes medications like insulin or sulfonylureas Symptoms include shakiness, sweating, and confusion Injection Site Reactions: Redness, swelling, or itching at the injection site Rare but Serious Side Effects Pancreatitis : Inflammation of the pancreas Symptoms include severe abdominal pain that may radiate to the back, nausea, and vomiting Gallbladder Problems: Such as gallstones or cholecystitis (inflammation of the gallbladder) Kidney Problems: Worsening of kidney function Allergic Reactions: Rash, itching, swelling, severe dizziness, or trouble breathing Thyroid Tumors: In animal studies, semaglutide has been associated with thyroid tumors, including cancer

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Many providers use both medications: metformin as affordable first-line treatment, with semaglutide added when additional improvement is needed or weight loss is prioritized