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10.1186/s12974-019-1571-8 16

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At the bottom of the orthosteric pocket, the side chain of R310 6.40b pointed to the TMD core and formed a cation-pi stacking with Y241 3.44b , where it pointed to ECL3 and made no contact with the TMD core in the GLP-1 bound structure

Clinical research priorities include properly designed human clinical trials with adequate sample sizes, appropriate controls, and validated outcome measures