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Low Representation, High Consumption Rates Cause Concern While accessibility data are indicative of potential underrepresentation in iCTs, they do not reflect an important variable, i.e., consumption of pharmaceuticals

Dysregulation across any of these interconnected epigenetic layers, from DNA methylation through histone marks to chromatin architecture and non-coding RNA networks, serves as biomarkers for oocyte developmental competence, highlighting the value of multi-level epigenetic assessment over single-mark analysis [181,182,183,184] Table 2

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