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Based on these findings, we suggest that novel therapeutic interventions should be sought that involve the combination of active agents, preferably agents with discrete modes of action, and which also exhibit activity against developmental stages, and/or which also ameliorate infection-associated pathology

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J Neurosci 25:78057812 Gordon PH, Moore DH, Miller RG et al (2007) Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial

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