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Physiology of refractory chronic constipation

JAMA Network Open, 2022 This retrospective study notes that patients who remained on lower doses of semaglutide experienced fewer side effectssuggesting that gradual titration and submaximal dosing may enhance tolerability without compromising outcomes

Starting at a low dose and escalating gradually reduces gastrointestinal side effects

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For example, a normally functioning body already produces collagen and GHRH, so adding collagen peptides or a GHRH analog should only enhance naturally occurring biological processes