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Nature 2018, 563: 194195

The cardiac pathology seen in these dogs is typical of positive inotropic drug toxicity in normal dog hearts, and is related to the physiologic effect of the drug on contractility and exaggerated hemodynamic response." On Vetmedin's website, it had this warning: "The safety of VETMEDIN has not been established in dogs with asymptomatic heart disease." Additionally, veterinary cardiologists spoke out against the pre-CHF use of pimobendan: Dr