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MOTS-C: A mitochondrial peptide that regulates energy production

Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis

According to the public registry, the trial was completed, and the results suggest a favorable safety profile with no significant adverse events reported (ClinicalTrials.gov Identifier: NCT03416053)

Converts white adipose tissue into brown adipose tissue (a phenomenon called fat tissue browning) to prevent body disfigurement associated with obesity and overweight

While this concept had been explored by academic groups and other pharmaceutical companies, Eli Lilly was uniquely positioned to execute it given their experience engineering multi-receptor peptides